Welcome to the Lab Mavilio, a unit dedicated to clinical and experimental immunology.

We are located at LITA in Segrate and at the Humanitas Research Hospital in Rozzano.

For years we have been dedicated to unraveling the complexities of the immune system, paving the way for innovative therapeutic approaches to various diseases.

Our team of highly skilled scientists, clinicians and researchers is driven by a passion for understanding the intricate mechanisms that regulate immune responses.

We use cutting-edge methods and technologies to unravel the complexities of innate immunity and explore its role in fighting infections, cancer and autoimmune diseases.

DOMENICO MAVILIO

Group Leader

Domenico Mavilio is a full professor of translational medicine at the Department of Medical Biotechnologies and Translational Medicine of the Medical School of the University of Milan.

Prof. Mavilio graduated from the Faculty of Medicine at the University of Genoa. He then obtained his PhD in Clinical and Experimental Immunology through a joint programme between the University of Genoa (Italy) and the National Institutes of Health (USA). After 9 years as a Research Fellow at the NIH, he was appointed Team Leader of the Laboratory of Clinical and Experimental Immunology at the Humanitas Research Hospital.

As physician, prof. Mavilio focuses his clinical activities on immunological disorders and hematologic malignancies. As a scientist, he handles research projects of translational medicine from the “bed-to bench” side aimed to study the pathogenesis and the cure of immunologic diseases.

Prof. Mavilio also currently serves as Adjunct Investigator at NIH and is a board member of Ph.D. Program in Experimental Medicine of Milan University. He is affiliated with several national and international scientific societies, is a member of the editorial boards of several international peer-reviewed scientific journals, deputy editor of the Journal of Leukocyte Biology (JLB), past elected member of the council of the Society of Leukocyte Biology (SLB), present elected member Italian Society of Immunology (SIICA), member of the ethical committee of the University of Milan “La Statale” .

Prof. Mavilio’s research is funded by grants from Italian Ministry of Health, Italian Ministry of University and Research, Fondazione Cariplo, Fondazione Umberto Veronesi, Associazione Italiana per la Ricerca sul Cancro (AIRC) and the European Union.

Meet the team

  • Silvia della bella

    MD, PhD, Senior Staff Scientist
    Curriculum Vitae
    ORCID: 0000-0003-0818-5049
    SCOPUS ID: 57252363900

    Silvia Della Bella is Associate Professor of General Pathology and Immunology at the Department of Medical Biotechnologies and Translational Medicine of the University of Milan, where she is responsible of courses in Degree Programs in Medicine and Surgery (Italian course and International Medical School) and in the Doctoral School in Experimental Medicine. Since 2011 she is Senior Staff Scientist in UCEI, where she leads a research group. Her current research activity is mainly focused on: immunobiology of human dendritic cells and their interactions with other immune cells in cancer and autoimmune diseases; investigation of endothelial dysfunction through the characterization of endothelial progenitors. Secretary of the European Society for Clinical cell Analysis (ESCCA) form 2014 to 2021, she is co-founder of UniMiFlow, the Flow Cytometry Academy of the University of Milan aimed at providing advanced training in flow cytometry.

  • clara di vito

    PhD, Senior Staff Scientist
    ORCID: 0000-0001-7248-1710
    SCOPUS ID: 56781393000

    Clara Di Vito is an Assistant Professor at the Department of Medical Biotechnologies and Translational Medicine of the University of Milan. Graduated in Medical Biotechnology at the University of Pavia in 2007, Dr Di Vito obtained her PhD in Molecular Medicine at the University of Eastern Piedmont in 2011. She then spent four years as post-doctoral fellow at the University of Milan, before moving to the Humanitas Research Hospital, Milan, Italy. Dr Di Vito joined UCEI in 2016 as senior Staff Scientist. Her research activities are focused on the investigation of the role of innate lymphoid cells in the etiology and severity of hematologic malignancies and their immune-reconstitution after hematopoietic stem cell transplantation. She is supported by Italian and European funding agencies (Fondazione Umberto Veronesi, EMBO and Italian Ministry of Health).

  • Francesca Calcaterra

    PhD, Senior Staff Scientist
    ORCID: 0000-0002-7625-1979
    SCOPUS ID: 56148439500

    Graduated in Medical Biotechnology and Molecular Medicine, she completed her PhD program in 2016 (University of Milan). As Staff scientist, she investigates the role of endothelial dysfunction in several pathological conditions (i.e. unprovoked venous thromboembolism, anti-phospholipid syndrome and oncohematologic patients receiving CAR-T cell therapy). She is also involved in research projects which investigate the innate and adaptive immunity in breast implant-associated Anaplastic large cells lymphoma (BIA-ALCL) and COVID-19. Her research activity is supported by several funding agencies (i.e. AIRC, Fondazione Umberto Veronesi, Fondazione Cariplo and Italian Ministry of Health).

  • Joanna Mikulak

    PhD, Senior Scientist
    ORCID: 0000-0001-8310-9543
    SCOPUS ID: 6507954160

    J. Mikulak joined UEI in 2006. She obtained her PhD in Biotechnology, specializing in regulatory mechanisms of HIV replication. Between 2006-2010, she studied the immune response in HIVAN at LIJ Medical Center, NY, USA. Currently, she coordinates scientific projects exploring the complexity of immune mechanisms in the pathogenesis of various tumors and viral infections, applying techniques such as multiparametric flow cytometry and RNA/TCR-seq.

  • Anna Carletti

    Lab Manager
    ORCID: 0000-0003-4468-2499

    Graduated in Medical Biotechnology and Molecular Medicine in 2022, Anna is the Laboratory Manager of Prof. Mavilio’s group. She not only coordinates the workflow of the group, but she also deals with grant and fund administration and she manages reagent orders, their transport timing and logistics. Moreover, she is responsible for tutoring new laboratory interns, processing different human samples and carrying out quality control activities of raw materials.

  • Michela Calvi

    Post-doctoral Fellow
    ORCID: 0000-0001-8603-5703
    SCOPUS ID: 57203287488

    Graduated in Medical Biotechnology and Molecular Medicine at the University of Milan in 2018, Dr Calvi obtained her PhD in Experimental Medicine at the University of Milan in 2023. She carries out research activities in the context of tumor immunology, with particular focus on the characterization of innate immune cells in hematologic malignancies to find out tumor immune escape mechanisms that could be targeted to ameliorate patient prognosis.

  • Assunta Cancellara

    Post-doctoral Fellow
    ORCID: 0000-0003-3395-3062
    SCOPUS ID: 58237743100

    Graduated in Medical Biotechnology, she obtained her PhD in Experimental Medicine studying the role endothelial dysfunction (ED) in unprovoked venous thromboembolism. She is currently investigating ED in pathological conditions through Endothelial colony-forming cells characterization. Moreover, she is studying the interplay between immune response, microbial colonization and surface textures in the pathogenesis of breast implant-associated Anaplastic large cells lymphoma.

  • Simone Balin

    PhD Student
    ORCID: 0000-0002-5343-2523
    SCOPUS ID: 58080368400

    Graduated in Medical Biotechnology and Molecular Medicine in 2022 at the University of Milan, Simone is now enrolled in the international PhD program in Experimental Medicine under the supervision of Professor Silvia Della Bella. His project is focused on the characterization of the immune dysregulation that occur in patients affected by thymic epithelial tumors, a model at the crossroad between cancer immunology and autoimmunity.

  • Valentina Cazzetta

    PhD Student
    ORCID: 0000-0001-7183-2793
    SCOPUS ID: 57212273640

    Graduated in Medical Biotechnology and Molecular Medicine, Valentina is now enrolled in the PhD program in Experimental Medicine at the University of Milan. She carries out research activities in the context of tumor immunology, in particular her focus is the numerical, phenotypical, functional and transcriptional characterization of innate immune cells (γδ T cells and NK cells) in solid tumors, including liver and gynecological cancers.

  • Roberta Ciceri

    PhD Student, social media manager
    ORCID: 0000-0003-2323-0346
    SCOPUS ID: 58291684200

    Roberta is enrolled in the PhD program in Experimental Medicine. Her project is focused on characterizing role and mechanisms of endothelial dysfunction (ED) in patients with Antiphospholypid Syndrome. She is also involved in projects related to ED in patients with unprovoked venous thromboembolism and the study of immunological milieu in patients with breast implant-associated anaplastic large cell lymphoma. In addition, Roberta is part of our social media management team.

  • Sara Franzese

    PhD Student
    ORCID: 0000-0002-2774-8719
    SCOPUS ID: 57220049441

    Graduated in Medical Biotechnology and Molecular Medicine at the University of Milan in 2020, Sara is enrolled in the PhD program in Experimental Medicine at the University of Milan. Her focus is the identification and characterization of autoreactive NK cells in patients affected by primary biliary cholangitis, taking advantage of multicolor flow cytometry and NGS techniques.

  • Alessandro Frigo

    PhD Student, graphic and social media manager
    ORCID: 0000-0002-7803-8549
    SCOPUS ID: 57751404400

    Alessandro is enrolled in the competitive PhD program in Experimental Medicine at Univeristy of Milan. His project focuses on the study of the physiological NK cell ontogenesis, its translation to the pathological one, to improve myelodysplastic syndromes classification and treatment, especially via bone marrow transplantation. Moreover, Alessandro participates in the management of our social media and creates illustrations and graphics.

  • Paolo Marzano

    PhD Student, Bioinformatician
    ORCID: 0000-0002-5614-4033
    SCOPUS ID: 57354186900

    Graduated at the Università degli Studi di Milano in the field of experimental immunology in 2022, Paolo is a PhD student in Experimental Medicine and is currently working as a bioinformatician. He’s mainly focused on the study and application of computational methods to analyze transcriptomic and proteomic data derived from multiparametric flow cytometry and single-cell–based RNA sequencing technologies to obtain a comprehensive analysis of the different immune cell types in tumors.

  • Sara Terzoli

    PhD Student, Bioinformatician
    ORCID: 0000-0003-2650-7195
    SCOPUS ID: 57225084925

    Graduated in Physics at the University of Milan in 2020. In 2020 she moved as bioinfomatician in the laboratory of Clinical and Experimental Immunology. From 2021, she has been enrolled in the PhD program in DASMEN at the Humanitas University. She is involved in the design and application of computational methods to analyze genomic and transcriptomic data by the Linux system and computational skills in bash scripting and Python and R languages.

  • Donatella Francesca Lattuada

    UnimiFlow Technical Referee
    ORCID: 0000-0002-0045-3283
    SCOPUS ID: 6603528515

    Donatella holds a Master's degree in Biological Sciences and a PhD in Experimental Pharmacology and Chemioterapy from the University of Milan, Italy. She is currently Professor on contract of "Human Physiology" in the Bachelor of Midwifery. She is the technical coordinator of the flow facility at the Department of Medical Biotechnology. Her research activity is focused on cellular model of depressive disorders.

  • Letizia Venturini

    UnimiFlow Technologist

    SCOPUS ID: 16067733600

    Graduated in Medical and Pharmaceutical Biotechnology, Dr Venturini obtained her PhD in Internal Medicine and Therapeutics at the University of Pavia. She gained 12 years of experience as a researcher in the Cellular Pathophysiology and Clinical Immunology Laboratory at the Department of Internal Medicine and Therapeutics of the at the University of Pavia. During this period, she also served as scientific consultant for freelanced collaborations. Dr Venturini joined UCEI in 2023 as Technologist of UnimiFlow.

  • Lara Orlandi

    Master’s degree Student

    After obtaining her Bachelor in Pharmaceutical Biotechnology, Dr Orlandi is currently enrolled in the Master course Medical Biotechnology and Molecular Medicine at University of Milan. In October 2023 she started her thesis internship, during which she is focusing on Innate Immune Cells (NK cells and ILC) in hematologic malignancies, also in response to therapeutic interventions, aiming to investigate their involvement in disease pathogenesis and progression.

  • Arianna Zancuoghi

    Master’s degree Student

    Graduated in Biotechnology at the University of Milan in 2022. Currently, she’s a master student in Medical Biotechnology and Molecular Medicine at the University of Milan.

Our former researchers:

Their accomplishments and achievements

  • Martina Defendi

    During her Master’s degree course in Medical biotechnology and Molecular Medicine at the University of Milan, Martina joined the "Unit of Clinical and Experimental Immunology" (UCEI) for a one-year internship working on the characterization of dendritic cells in thymoma epithelial lesions from patients showing comorbidity with autoimmune disorders.

    Today, miss Defendi is working as a technical assistant in a startup in Berlin, focusing on the development of cell therapy against tumours.

  • Nicolò Coianiz

    After obtaining his Master’s degree in industrial biotechnology at the University of Milano-Bicocca, Nicolò joined the "Unit of Clinical and Experimental Immunology" (UCEI) as a research fellow participating to the characterization of NK cell immune-reconstitution after h-HSCT and the response to SARS-CoV-2 vaccination.

    Today, Dr. Coianiz is enrolled as a PhD student in Cancer Biology in the "Institute of Experimental Immunology" at the University of Zurich.

  • Elisa zaghi

    After obtaining her Master’s degree in applied and Experimental Biology at the University of Pavia in 2015, Dr Zaghi moved the UCEI for her PhD program. During this period, she was focused on unrevealing the kinetic and alloreactive responses of innate cell immune-reconstitution in patients with hematologic malignances undergoing transplantation. She also participated in the characterization of “memory-like” NK cells expanded upon cytomegalovirus infection in these patients.

    Currently, she works a Senior Scientist at Sanofi evaluating new immunotherapies for hematologic cancers.

  • Ferdinando Oriolo

    After obtaining a master's degree in experimental and applied biology at the University of Pavia. Dr Oriolo began a doctoral project working between UNIMI and NIH studying the role of γδ T cells in colorectal cancer and various autoinflammatory diseases.

    He currently holds the role of Field medical lead for the oncology line in daiichi-sankyo

  • Monica Cappelletti

    Dr. Cappelletti earned her MS in Medical Biotechnology and her PhD in Molecular Medicine at the University of Milan in Prof. Della Bella and Mavilio’s lab, focusing on the immunological processes associated with the alteration of immune cell populations in pregnancy disorders. She moved to Cincinnati Children’s Hospital in Dr. Divanovic’s lab for her post-doc. She was recruited to UCLA in Dr. Kallapur’s lab and her project was focused on preclinical evaluation of promising drugs to prevent inflammation associated preterm labor.

    Currently, she is Assistant Professor in the Dept. of Pathology and Lab Medicine.