Evolution of the Immune Landscape in the Progression of Gynecological Cancers

The prevalent gynecologic cancers, endometrial and ovarian, are the focus of our study aimed to unveil immune dynamics in their development, diagnosis, and progression.

Employing tissue-engineered cell-based in vitro models that mimic many aspects of the complex endometrial and ovarian tumor microenvironment, we systematically investigate the immune response in correlation with the tumor stage. This analysis involves dissecting phenotypic, effector and transcriptional changes through combination of flow cytometry and RNA/TCR-seq technics, complemented by advanced biostatistician tools, encompassing cutting-edge algorithms and statistical models.

Our approach seeks to advance diagnostic precision and facilities the development of personalized immunotherapies for gynecological malignances.

TEAM

Joanna Mikulak PhD - Senior staff scientist

Valentina Cazzetta - Post-doctoral fellow

Paolo Marzano - PhD student, bioinformatician

Annalisa Imperiali - PhD student, bioinformatician

Anna Carletti – Lab manager

collaborations

Gynecology Unit
IRCCS Humanitas Research Hospital, Milan, Italy

Unit of Gynecological Oncology Research
IEO, Milan, Italy

Cancer Pharmacology Lab
IRCCS Humanitas Research Hospital, Milan, Italy

Pathology Unit
IRCCS Humanitas Research Hospital, Rozzano, Milan

Dipartimento di Medicina Sperimentale
Università degli Studi di Genova, Genova, Italy

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