Contribution of innate immune cells in glioma immune escape
Diffuse glioma is an aggressive brain cancer characterized by poor prognosis and a highly immunosuppressive tumor microenvironment.
Aim of this project is to characterize at a single-cell level glioma-infiltrating innate immune cells, to investigate their contribution to tumor immune escape.
The comprehension of the cellular and molecular changes these cells undergo in the glioma microenvironment will be useful to improve the follow-up of these patients and to develop immunotherapeutic treatments aimed at reactivating tumor-specific immune responses.
TEAM
Silvia Della Bella MD, PhD - Senior staff scientist
Simone Balin - PhD student
fundings
Associazione Italiana per la Ricerca sul Cancro
AIRC
Project ID: IG 14687
Humanitas Research Hospital
Intramural Research and Clinical Funding Programs 5x1000 2018
Associazione Italiana per la Ricerca sul Cancro
AIRC
Project ID: IG 19213
Ministero della Salute
Project ID: RF 2019-12371549)
Department of Medical Biotechnologies and Translational Medicine, University of Milan
2019 and 2020 Intramural Programs
collaborations
Bioinformatics Unit
IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Department of Medical Oncology and Hematology
IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Department of Neurosurgery
IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Laboratory of Chemokine Biology
IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Laboratory of Leukocyte Biology
IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Department of Biomedical Sciences
Humanitas University, Pieve Emanuele, Milan, Italy
Unit of Oncological Neurosurgery
IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
Department of Medical Biotechnologies and Translational Medicine
University of Milan, Milan, Italy
Department of Oncology and Hemato-Oncology
University of Milan, Milan, Italy
Genomic Research Centre
Human Technopole, Milan, Italy
Institute of Genetic and Biomedical Research
National Research Council, Rozzano, Milan, Italy
related publications
Carenza C, Franzese S, Castagna A, Terzoli S, Simonelli M, Persico P, Bello L, Nibali MC, Pessina F, Kunderfranco P, Peano C, Balin S, Mikulak J, Calcaterra F, Bonecchi R, Savino B, Locati M, Della Bella S, Mavilio D.
Front Immunol. 2023 Jan 10;13:1074762. doi: 10.3389/fimmu.2022.1074762.Comprehensive Phenotyping of Dendritic Cells in Cancer Patients by Flow Cytometry
Carenza C, Franzese S, Calcaterra F, Mavilio D, Della Bella S.
Cytometry A. 2021 Mar;99(3):218-230. doi: 10.1002/cyto.a.24245.Simonelli M, Persico P, Capucetti A, Carenza C, Franzese S, Lorenzi E, Dipasquale A, Losurdo A, Giordano L, Pessina F, Navarria P, Politi LS, Mavilio D, Locati M, Della Bella S, Santoro A, Bonecchi R.
Neurooncol Adv. 2021 Nov 13;3(1):vdab160. doi: 10.1093/noajnl/vdab160.Role of myeloid cells in the immunosuppressive microenvironment in gliomas
Locarno CV, Simonelli M, Carenza C, Capucetti A, Stanzani E, Lorenzi E, Persico P, Della Bella S, Passoni L, Mavilio D, Bonecchi R, Locati M, Savino B.
Immunobiology. 2020 Jan;225(1):151853. doi: 10.1016/j.imbio.2019.10.002.