The pathogenesis of COVID-19 is multifactorial and complicated, as SARS-CoV-2 can cause a broad range of clinical manifestations. Differences in the outcome of the disease could be linked to uncontrolled immune responses. Therefore, understanding the specific innate and adaptive immune mechanisms is crucial for effective treatment.

Thus, our research project focuses on investigating the role of the innate and the adaptive immune system in protecting against SARS-CoV-2 infection both in a longitudinally monitored cohort of vaccinated healthy subjects, pre-and post-BNT162b2 vaccine administration and in a heterogeneous cohort of both unvaccinated and vaccinated COVID-19 patients.

We employ multi-omics approaches, including 5’ scRNA-seq paired with scTCR-seq, CITE-seq, and multiome.